The effect of sleep deprivation on memory and psychomotor function in healthy volunteers

SummaryModafinil is a new psychotropic compound with central α1, adrenergic-stimulant activity in animals. In the present study, its pharmacological activity in man was evaluated in the sleep-deprivation induced psychomotor and cognitive impairment paradigm. This was a double-blind placebo-controlled study involving 12 healthy volunteers. Standard psychomotor and memory tasks were used, including critical flicker fusion frequency determination (CFF), choice reaction time and short- and long-term memory evaluation. Results revealed a clear antagonism by modafinil of the psychomotor and cognitive impairment induced by sleep-deprivation in most tasks 6 h after drug administration, and marginal effects 18 h after. These results therefore support a psychostimulant activity of modafinil in man.

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Effects of different sleep deprivation protocols on sleep perception in healthy volunteers

Sleep Medicine ◽

10.1016/j.sleep.2014.05.025 ◽

2014 ◽

Vol 15 (10) ◽

pp. 1219-1224 ◽

Cited By ~ 9

Author(s):

Leonardo I. Goulart ◽

Luciano R. Pinto ◽

Michael L. Perlis ◽

Raquel Martins ◽

Luis Otavio Caboclo ◽

...

Keyword(s):

Sleep Deprivation ◽

Healthy Volunteers

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Comparative study of acute effects of single doses of fexofenadine, olopatadine,d-chlorpheniramine and placebo on psychomotor function in healthy volunteers

Human Psychopharmacology Clinical and Experimental ◽

10.1002/hup.538 ◽

2003 ◽

Vol 18 (8) ◽

pp. 611-618 ◽

Cited By ~ 18

Author(s):

Hiroyuki Kamei ◽

Yukihiro Noda ◽

Kazuhiro Ishikawa ◽

Koji Senzaki ◽

Isao Muraoka ◽

...

Keyword(s):

Comparative Study ◽

Healthy Volunteers ◽

Psychomotor Function ◽

Acute Effects

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Effects of butoctamide hydrogen succinate and nitrazepam on psychomotor function and EEG in healthy volunteers

Psychopharmacology ◽

10.1007/bf00439453 ◽

1989 ◽

Vol 97 (3) ◽

pp. 370-375 ◽

Cited By ~ 6

Author(s):

Takuji Tazaki ◽

Koji Tada ◽

Yoshimi Nogami ◽

Nobuo Takemura ◽

Koichi Ishikawa

Keyword(s):

Healthy Volunteers ◽

Psychomotor Function

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Effects of Total Sleep Deprivation on Cardiovascular Parameters: An Absence of Biologically Significant Findings?

Journal of Psychophysiology ◽

10.1027//0269-8803.16.2.119 ◽

2002 ◽

Vol 16 (2) ◽

pp. 119-126 ◽

Cited By ~ 1

Author(s):

Elena Miró ◽

Carmen Cano ◽

Gualberto Buela-Casal

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Sleep Deprivation ◽

Healthy Volunteers ◽

Repeated Measures ◽

Clinical Relevance ◽

Vigilance Task ◽

Mean Values ◽

Total Sleep Deprivation ◽

The Third

Abstract The present study analyzes the variations of heart rate (HR) and systolic and diastolic blood pressure (SBP and DBP) during 60 h of total sleep deprivation (TSD). All variables were evaluated every 2 h in a resting condition, during the performance of a vigilance task. Thirty healthy volunteers (15 men and 15 women) from 18 to 24 years old participated in the experiment. The analyses of variance (ANOVAS) with repeated measures showed some modifications of HR and SBP mean values mainly marked by circadian oscillations. The circadian oscillations had a smaller amplitude for SBP than for HR. HR showed a slight decrease on the second night of TSD and a slight increase on the third day of TSD. SBP decreased during the first 24 h of TSD and after that maintained its values without significant changes. DBP did not show any significant variations during TSD. In addition, there were no differences in function of gender for the TSD effect on the studied variables. All these statistically significant findings, however, seem to have no biological or clinical relevance. These aspects as well as the possible relationships between our results and activation or stress levels during TSD are discussed.

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